About Esketamine Spravato®

The first nasal spray medication for treatment-resistant depression.

Ketamine is a medication that has been used as a surgical anesthesia around the world for more than 50 years with children, adults, and animals.  About 20 years ago, ketamine’s ability to relieve depression, anxiety, and some pain disorders in less than 24 hours after administration was stumbled upon by researchers. Follow-up studies replicating the rapid results have changed researchers’ understanding of depression, revitalizing an area of medical research that had been stagnant for almost three decades.

Esketamine, or Spravato, is derived from ketamine and makes powerful antidepressant relief available to be delivered intra-nasally, similar to a common nasal decongestant. Sunny Hills offers esketamine therapy, and this novel therapy for treatment-resistant depression can be combined with other treatment modalities, such as antidepressants, Transcranial Magnetic Stimulation (TMS), or other therapies.

Is Spravato® right for you?

At Sunny Hills our doctors are experts at evaluating your specific needs and the medications you have tried in the past. During your initial evaluation, we will review your medical history and together map out a treatment plan that is best for you.


Frequently Asked Questions

Esketamine, or Spravato, is the first nasal spray medication that is a treatment for depression. Combined with an antidepressant, Spravato is FDA-approved to treat depression and has been clinically shown to improve symptoms of depression over just 4 weeks.

Unlike typical antidepressants, Spravato is the only drug that works on the glutamate receptor. (There is no other medication that works like this).

  • Plan to be at our office for 2.5 hours.
  • No food for 2 hours before treatment.
  • You can have fluid up to 30 minutes before treatment.
  • You must have someone pick you up and drive you home after treatment.
  • During treatment you are resting comfortably and being closely monitored
    by our medical team.
  • You can take your regular medications with a sip of water but you need to
    avoid taking any benzodiazepine medication such as: Xanax, Klonopin,
    Ativan or Valium on the day of treatment.

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